Vakayil was born at Vakayil Family in Koonammavu, as the second child of Paily and Francisca. He started his lessons of catechism and academic studies at St.Philomena's Forane Church, Koonammavu and the school affiliated to the said church. He lost his mother at the age of seven.George Vakayil and was taken care of by his elder brother’s wife. Vakayil was keen on attending the holy mass every day and he served as an altar boy in his home parish. He joined St. Albert's High School, Ernakulam and passed the matriculation. Later he joined in Puthanpalli Seminary where he completed his pastoral studies.

Vakayil served at Good Sheperd’s Church at Kottayam, Churches at Kurichi and Thottakam. It was reported that, when he was serving as a priest at Kurichi, he met with an accident while he was moving in cycle through a hilly area. Kurichi was a hilly area where he worked among the poor and downtrodden. He was instrumental in constructing houses for the destitute, helping the poor and ailing patients etc.